Daily Papers

Tuning the regularization parameter in penalized regression models is an expensive task, requiring multiple models to be fit along a path of parameters. Strong screening rules drastically reduce computational costs by lowering the dimensionality of the input prior to fitting. We develop strong screening rules for group-based Sorted L-One Penalized Estimation (SLOPE) models: Group SLOPE and Sparse-group SLOPE. The developed rules are applicable to the wider family of group-based OWL models, including OSCAR. Our experiments on both synthetic and real data show that the screening rules significantly accelerate the fitting process. The screening rules make it accessible for group SLOPE and sparse-group SLOPE to be applied to high-dimensional datasets, particularly those encountered in genetics.

As orbital populations grow, conjunction screening must search more object pairs for potential collision risks. Existing pipelines use early-stage filters, such as an apsis filter, to eliminate pairs whose orbital altitude ranges cannot produce a close approach. However, these filters apply the same fixed threshold to every object, making the screening unnecessarily conservative for well-constrained objects while potentially insufficient for objects with greater orbit-prediction uncertainty. In this work, we present an uncertainty-aware conjunction screening method that replaces a single fixed apsis threshold with object-specific thresholds derived from propagated radial uncertainty. The resulting thresholds vary across both objects and prediction time, becoming narrower when propagated uncertainty is small and wider when uncertainty grows. We pair this adaptive screening rule with a binary-search altitude sweep that makes resulting heterogeneous intervals efficient to evaluate at catalog scale with log-linear search complexity. We evaluate the method on 33,791 objects from the Space-Track General Perturbations (GP) catalog using the preceding eight public ephemeris snapshots and a seven-day prediction horizon. The adaptive sieve retains 162.8 million candidate pairs, reducing the candidate set by 28.78% relative to a fixed 50 km apsis threshold and by 71.48% relative to brute-force all-pairs screening. It retains all close approaches identified in two independently propagated reference sets. At the largest tested catalog size, the binary-search sweep is 27 times faster than exhaustive interval evaluation while returning the same candidate set. These results demonstrate that uncertainty-aware screening can substantially reduce the candidate burden passed to downstream conjunction analysis, providing a scalable path toward managing increasingly large and heterogeneous orbital populations.

The validity screen (Cacioli, 2026d, 2026e) classifies LLM confidence signals as Valid, Indeterminate, or Invalid. We test whether these classifications predict selective prediction performance. Twenty frontier LLMs from seven families were evaluated on 524 items across six cognitive tracks. Valid models show mean Type 2 AUROC = .624 (SD = .048). Invalid models show mean AUROC = .357 (SD = .231). Cohen's d = 2.81, p = .002. The tiers order monotonically: Invalid (.357) < Indeterminate (.554) < Valid (.624). Split-half cross-validation yields median d = 1.77, P(d > 0) = 1.0 across 1,000 splits. The three-tier classification accounts for 47% of the variance in AUROC. DeepSeek-R1 drops from 85.3% accuracy at full coverage to 11.3% at 10% coverage. The screen predicts the criterion. For selective prediction, the screen matters.

Medical systematic reviews typically require assessing all the documents retrieved by a search. The reason is two-fold: the task aims for ``total recall''; and documents retrieved using Boolean search are an unordered set, and thus it is unclear how an assessor could examine only a subset. Screening prioritisation is the process of ranking the (unordered) set of retrieved documents, allowing assessors to begin the downstream processes of the systematic review creation earlier, leading to earlier completion of the review, or even avoiding screening documents ranked least relevant. Screening prioritisation requires highly effective ranking methods. Pre-trained language models are state-of-the-art on many IR tasks but have yet to be applied to systematic review screening prioritisation. In this paper, we apply several pre-trained language models to the systematic review document ranking task, both directly and fine-tuned. An empirical analysis compares how effective neural methods compare to traditional methods for this task. We also investigate different types of document representations for neural methods and their impact on ranking performance. Our results show that BERT-based rankers outperform the current state-of-the-art screening prioritisation methods. However, BERT rankers and existing methods can actually be complementary, and thus, further improvements may be achieved if used in conjunction.

Side-channel evaluators routinely inspect leakage tests while acquisition is still running, and extend or stop the campaign based on what they see. Fixed-horizon screening such as the Welch t-test with threshold |t|>4.5 gives no error guarantee for this monitored decision rule. We study anytime-valid leakage detection based on testing by betting: SKIT-type swap-pair e-processes whose false-alarm probability is controlled uniformly over time under an explicit conditional symmetry null. In matched comparisons that share the frozen witness, rows and payoff, first-crossing detection needed 1.68-2.00times the traces of a fixed-horizon randomization test at 80% detection on synthetic streams, and 1.68-2.38times on degraded recordings from an open ML-KEM electromagnetic dataset with the primary Ridge witness at α=0.05. With the same primary witness and level, on undegraded reference and pqm4 recordings the monitored procedure stopped early: its median stopping point was 62-72 and 146-316 evaluation traces, i.e. 2-8% of a conservative 4096-trace budget. Under exact designed nulls on the recorded backgrounds, repeated-look |t|>4.5 screening over all 13000-20000 samples raised a false alarm in 2.7-12.9% of replicates, against 0.0-4.7% for terminal-only screening and no rejection by a sample-wise e-Bonferroni process, which in a prespecified follow-up detected natural-label associations in 4 of 4 backgrounds after 840-3288 traces. All recordings come from one device, and natural-label results are descriptive; we state the assumptions each claim requires.

Two critical limitations of organic-inorganic lead halide perovskite materials for solar cells are their poor stability in humid environments and inclusion of toxic lead. In this study, high-throughput density functional theory (DFT) methods are used to computationally model and screen 1845 halide perovskites in search of new materials without these limitations that are promising for solar cell applications. This study focuses on finding materials that are comprised of nontoxic elements, stable in a humid operating environment, and have an optimal bandgap for one of single junction, tandem Si-perovskite, or quantum dot-based solar cells. Single junction materials are also screened on predicted single junction photovoltaic (PV) efficiencies exceeding 22.7%, which is the current highest reported PV efficiency for halide perovskites. Generally, these methods qualitatively reproduce the properties of known promising nontoxic halide perovskites that have either been experimentally evaluated or predicted from theory. From a set of 1845 materials, 15 materials pass all screening criteria for single junction cell applications, 13 of which have not been previously investigated, such as (CH3NH3)0.75Cs0.25SnI3, ((NH2)2CH)Ag0.5Sb0.5Br3, CsMn0.875Fe0.125I3, ((CH3)2NH2)Ag0.5Bi0.5I3, and ((NH2)2CH)0.5Rb0.5SnI3. These materials, together with others predicted in this study, may be promising candidate materials for stable, highly efficient, and non-toxic perovskite-based solar cells.

By organizing knowledge within a research field, Systematic Reviews (SR) provide valuable leads to steer research. Evidence suggests that SRs have become first-class artifacts in software engineering. However, the tedious manual effort associated with the screening phase of SRs renders these studies a costly and error-prone endeavor. While screening has traditionally been considered not amenable to automation, the advent of generative AI-driven chatbots, backed with large language models is set to disrupt the field. In this report, we propose an approach to leverage these novel technological developments for automating the screening of SRs. We assess the consistency, classification performance, and generalizability of ChatGPT in screening articles for SRs and compare these figures with those of traditional classifiers used in SR automation. Our results indicate that ChatGPT is a viable option to automate the SR processes, but requires careful considerations from developers when integrating ChatGPT into their SR tools.

Machine learning models routinely automate decisions in applications like lending and hiring. In such settings, consumer protection rules require companies that deploy models to explain predictions to decision subjects. These rules are motivated, in part, by the belief that explanations can promote recourse by revealing information that individuals can use to contest or improve their outcomes. In practice, many companies comply with these rules by providing individuals with a list of the most important features for their prediction, which they identify based on feature importance scores from feature attribution methods such as SHAP or LIME. In this work, we show how these practices can undermine consumers by highlighting features that would not lead to an improved outcome and by explaining predictions that cannot be changed. We propose to address these issues by highlighting features based on their responsiveness score -- i.e., the probability that an individual can attain a target prediction by changing a specific feature. We develop efficient methods to compute responsiveness scores for any model and any dataset. We conduct an extensive empirical study on the responsiveness of explanations in lending. Our results show that standard practices in consumer finance can backfire by presenting consumers with reasons without recourse, and demonstrate how our approach improves consumer protection by highlighting responsive features and identifying fixed predictions.

In ophthalmology, early fundus screening is an economic and effective way to prevent blindness caused by ophthalmic diseases. Clinically, due to the lack of medical resources, manual diagnosis is time-consuming and may delay the condition. With the development of deep learning, some researches on ophthalmic diseases have achieved good results, however, most of them are just based on one disease. During fundus screening, ophthalmologists usually give diagnoses of multi-disease on binocular fundus image, so we release a dataset with 8 diseases to meet the real medical scene, which contains 10,000 fundus images from both eyes of 5,000 patients. We did some benchmark experiments on it through some state-of-the-art deep neural networks. We found simply increasing the scale of network cannot bring good results for multi-disease classification, and a well-structured feature fusion method combines characteristics of multi-disease is needed. Through this work, we hope to advance the research of related fields.

With an estimated 160,000 deaths in 2018, lung cancer is the most common cause of cancer death in the United States. Lung cancer CT screening has been shown to reduce mortality by up to 40% and is now included in US screening guidelines. Reducing the high error rates in lung cancer screening is imperative because of the high clinical and financial costs caused by diagnosis mistakes. Despite the use of standards for radiological diagnosis, persistent inter-grader variability and incomplete characterization of comprehensive imaging findings remain as limitations of current methods. These limitations suggest opportunities for more sophisticated systems to improve performance and inter-reader consistency. In this report, we reproduce a state-of-the-art deep learning algorithm for lung cancer risk prediction. Our model predicts malignancy probability and risk bucket classification from lung CT studies. This allows for risk categorization of patients being screened and suggests the most appropriate surveillance and management. Combining our solution high accuracy, consistency and fully automated nature, our approach may enable highly efficient screening procedures and accelerate the adoption of lung cancer screening.

Recursive synthetic-data training can degrade a fitted model, but its effects on the variable-screening stage that precedes model fitting are less understood. When each generation labels data for the next, a marginal screener ranks variables against the current pseudo-label target rather than the original response. Across generations, this target drift can erode or reverse the active--inactive score margin and cause screening to discard variables that clean-label screening would retain. We call this process screening collapse. In a Gaussian linear model with minimum-norm recursive generators, we establish finite-sample screening bounds, characterize a late-generation information-loss limit, and derive a minimax impossibility result. Screening collapse can precede and compound ordinary model collapse: omitted variables incur a covariance-weighted loss that no refit restricted to the selected variables can eliminate, while recursive labels further degrade estimation on the retained variables. We also examine two approaches to mitigating screening collapse. Fixed-fraction real-label retention preserves a clean-label component but leaves resolution fixed, whereas data accumulation can avoid screening collapse if the pooled target preserves a positive margin and the growing sample resolves it. Numerical experiments on gene-expression data support the theoretical findings.

Colorectal cancer (CRC) is the third cause of cancer death worldwide. Currently, the standard approach to reduce CRC-related mortality is to perform regular screening in search for polyps and colonoscopy is the screening tool of choice. The main limitations of this screening procedure are polyp miss-rate and inability to perform visual assessment of polyp malignancy. These drawbacks can be reduced by designing Decision Support Systems (DSS) aiming to help clinicians in the different stages of the procedure by providing endoluminal scene segmentation. Thus, in this paper, we introduce an extended benchmark of colonoscopy image, with the hope of establishing a new strong benchmark for colonoscopy image analysis research. We provide new baselines on this dataset by training standard fully convolutional networks (FCN) for semantic segmentation and significantly outperforming, without any further post-processing, prior results in endoluminal scene segmentation.

Agent skills turn natural-language instructions into actions, creating a security challenge: legitimate automation and malicious behaviour can look deceptively similar. A practical screen must catch nearly every attack while keeping the review load manageable. We present SkillScreen, a compact decision model trained to score skill maliciousness directly from SKILL.md in a single forward pass. On MaliciousSkillBench, SkillScreen flags 20-25% of benign skills at 99% recall on unseen attack families, substantially fewer than the word-level classifier and prompted LLM judges tested. Under the same training protocol, it also generalizes better than a fully fine-tuned encoder to unseen sources. Yet unfamiliar benign sources sharply increase false positives, showing that recognizing new attacks does not ensure reliable screening of new skill collections. Our results demonstrate the value of task-trained decision models for high-recall skill screening. Project page: https://jerroldh.github.io/SkillScreen-webpage/

Automated mammography screening plays an important role in early breast cancer detection. However, current machine learning models, developed on some training datasets, may exhibit performance degradation and bias when deployed in real-world settings. In this paper, we analyze the performance of high-performing AI models on two mammography datasets-the Emory Breast Imaging Dataset (EMBED) and the RSNA 2022 challenge dataset. Specifically, we evaluate how these models perform across different subgroups, defined by six attributes, to detect potential biases using a range of classification metrics. Our analysis identifies certain subgroups that demonstrate notable underperformance, highlighting the need for ongoing monitoring of these subgroups' performance. To address this, we adopt a monitoring method designed to detect performance drifts over time. Upon identifying a drift, this method issues an alert, which can enable timely interventions. This approach not only provides a tool for tracking the performance but also helps ensure that AI models continue to perform effectively across diverse populations.

Computer-use agents plan on a screenshot for several seconds and then click at a position on the screen; if the page has changed in the meantime, the click lands on an unintended element. Prior work treats the planning interval as the source of this risk. Measuring planned clicks on 31 public web pages, we find that the risk lies in page loading: 0.4% of clicks planned on fully loaded pages became stale within 30 seconds, against 17% of clicks planned in the first second after a page opened. On these pages, waiting about one second for network activity to stop removes most of this risk, yet the wait rules of eight of ten widely used open-source agents leave more than 1% of clicks stale. Commercial pages keep loading for longer: in the HTTP Archive's public crawl, 15% of 65 desktop booking and buying home pages went 500 ms without network requests within 3 seconds of their HTML being parsed, against 63% of 3,028 .gov pages, and 52% shifted their layout within 6.5 seconds of a network-idle wait capped at 3 seconds, against 8% (61% against 26% among pages recorded in full). Where a check before the click is needed, as before irreversible actions and on pages that are still loading, a pixel comparison verifies the target's position as accurately as a frontier vision-language model at one eighth of the latency, and a 4B model matches the frontier model in verifying whether the previous action succeeded. We release a benchmark generator, a break-even formula for when a check pays, and three rules for agent developers: https://github.com/multimodal-ai-engineering/preflight-bench

Safety monitors screen prompts sent to deployed language models, flagging harmful requests so they are never answered. They are evaluated by recall against harmfulness labels, but a catch only prevents harm if the model would otherwise have complied. We measure the difference directly: we sample repeated responses from the target model, call a harmful prompt elicitable if the model complies at least once, and report monitor recall separately on elicitable and non-elicitable prompts. Across six monitor configurations and three model families, spanning activation probes, fine-tuned text guards, and a 120B policy-conditioned reasoning classifier, recall on elicitable prompts falls 0.22 to 0.38 below recall on non-elicitable prompts at a fixed false positive rate. The prompts a monitor misses are 2.8 to 5.6 times more likely to be complied with than the prompts it catches. The gap replicates across three model families and appears also in text-only monitors entirely independent of the target model. This suggests that standard recall may overstate the protection monitors provide in practice, and that monitors should be evaluated against what their models will actually answer.

When developing deep neural networks for segmenting intraoperative ultrasound images, several practical issues are encountered frequently, such as the presence of ultrasound frames that do not contain regions of interest and the high variance in ground-truth labels. In this study, we evaluate the utility of a pre-screening classification network prior to the segmentation network. Experimental results demonstrate that such a classifier, minimising frame classification errors, was able to directly impact the number of false positive and false negative frames. Importantly, the segmentation accuracy on the classifier-selected frames, that would be segmented, remains comparable to or better than those from standalone segmentation networks. Interestingly, the efficacy of the pre-screening classifier was affected by the sampling methods for training labels from multiple observers, a seemingly independent problem. We show experimentally that a previously proposed approach, combining random sampling and consensus labels, may need to be adapted to perform well in our application. Furthermore, this work aims to share practical experience in developing a machine learning application that assists highly variable interventional imaging for prostate cancer patients, to present robust and reproducible open-source implementations, and to report a set of comprehensive results and analysis comparing these practical, yet important, options in a real-world clinical application.

This study presents a hybrid framework for predicting movie success. The framework integrates multi-task learning (MTL), GPT-based sentiment analysis, and Susceptible-Infected-Recovered (SIR) propagation modeling. The study examines limitations in existing approaches. It models static production attributes, information dissemination, and audience sentiment at the same time. The framework uses 5,840 films from 2004 to 2024 and approximate 300,000 user reviews. It shows predictive performance with classification accuracy of 0.964 and regression metrics of MAE 0.388. Ablation analysis indicates component interactions. Selective feature combinations perform better than the comprehensive model. This result questions assumptions about feature integration. The model shows virality patterns between successful and unsuccessful films. Innovations include epidemiological modeling for information diffusion, multidimensional sentiment features from GPT-based analysis, and a shared representation architecture that optimizes multiple success metrics. The framework provides applications in the film production lifecycle. It also contributes to understanding how audience engagement leads to commercial outcomes.

We present RuleChef, a framework that uses large language models (LLMs) to generate executable rules for NLP tasks such as text classification, Named Entity Recognition (NER), or relation extraction. Rules are generated based on a task description and a set of labeled examples, then they are iteratively improved based both on additional examples and on human feedback overexisting rules. RuleChef can also be used to bootstrap rules using the observed input-output pairs from any existing model for a given task. LLMs are used only at learning time, synthesizing rules and iteratively patching them based on failures measured on a held-out split. The result of this process is a fast, deterministic, and inspectable rule system. Preliminary evaluation is performed on both classification and NER tasks. We release RuleChef as open-source software under an Apache 2.0

In critical applications, it is vital for classifiers to defer decision-making to humans. We propose a post-hoc method that makes existing classifiers selectively abstain from predicting certain samples. Our abstaining classifier is incentivized to maintain the original accuracy for each sub-population (i.e. no harm) while achieving a set of group fairness definitions to a user specified degree. To this end, we design an Integer Programming (IP) procedure that assigns abstention decisions for each training sample to satisfy a set of constraints. To generalize the abstaining decisions to test samples, we then train a surrogate model to learn the abstaining decisions based on the IP solutions in an end-to-end manner. We analyze the feasibility of the IP procedure to determine the possible abstention rate for different levels of unfairness tolerance and accuracy constraint for achieving no harm. To the best of our knowledge, this work is the first to identify the theoretical relationships between the constraint parameters and the required abstention rate. Our theoretical results are important since a high abstention rate is often infeasible in practice due to a lack of human resources. Our framework outperforms existing methods in terms of fairness disparity without sacrificing accuracy at similar abstention rates.

Many Indian banks serve customers through FAQ pages and scripted chatbots. Assistants based on language models could respond faster and carry out requests such as blocking a card, but only if they give correct information and follow the bank's rules. These rules prescribe a procedure, a set of required steps, such as obtaining a closure quote before closing a deposit. Adapting models to this domain requires measuring how well they follow the procedure, before and after training. Benchmarks usually judge only the records left at the end of a conversation. Many required steps, however, leave the records unchanged, so an assistant that skips them can still be judged successful. We present TauIndianBankBench, an action-oriented benchmark of 1,000 Indian retail-banking tasks where an assistant helps a simulated customer. Besides the final records, it checks that the assistant took every required step and made no unrequested change. For every model, 6.5-12.0% of sessions are judged successful when only the final records are checked, although the assistant skipped a required step or made an unrequested change. Scoring both procedure and outcome shows more accurately how well language models perform in Indian retail banking.

Robots that store past experiences must select which one to reuse in a new scene. Most systems select by visual similarity, and most evaluations report only the success of the selected experience. That number does not show whether the selection was good: a rule can score well by repeatedly using one broadly transferable experience, or poorly because its preferred experience is weak. Since robots increasingly adapt by reuse rather than retraining, a score that describes the library rather than the rule misleads what the field builds next. We contribute an audit methodology: execute every stored experience in every query scene, over two manipulation tasks, three reuse mechanisms, and libraries of K=3, 10, and 50. Because every alternative's outcome is known, a score can be traced to per-scene selection or to library quality. The audited rules select by nearest-neighbor distance in five visual embeddings, from raw pixels to CLIP. (1) One fixed experience, chosen with hindsight, captures 30-58% of the gap between random selection and an oracle; per-scene selection competes for the remaining 0.07-0.15 in success rate. (2) At Kge10, visual rules concentrate on one experience 1.5-3 times more than the oracle does, and their scores then follow that experience's quality. (3) Wherever a rule differs significantly from a shuffle that keeps its selection rates but pairs them with scenes at random, the rule is worse, for every learned image policy. (4) Visual distance predicts well whether a given pair will succeed (AUROC up to 0.96), yet ranks the candidates within one scene no better than chance for four of five embeddings at K=50 (AUROC 0.45-0.52). Exhaustive execution is usually infeasible, so the audit reduces to two cheap reports any study can give: the distribution of selected experiences, and the success of the best single experience in hindsight.

Pan-cancer screening in large-scale CT scans remains challenging for existing AI methods, primarily due to the difficulty of localizing diverse types of tiny lesions in large CT volumes. The extreme foreground-background imbalance significantly hinders models from focusing on diseased regions, while redundant focus on healthy regions not only decreases the efficiency but also increases false positives. Inspired by radiologists' glance and focus diagnostic strategy, we introduce GF-Screen, a Glance and Focus reinforcement learning framework for pan-cancer screening. GF-Screen employs a Glance model to localize the diseased regions and a Focus model to precisely segment the lesions, where segmentation results of the Focus model are leveraged to reward the Glance model via Reinforcement Learning (RL). Specifically, the Glance model crops a group of sub-volumes from the entire CT volume and learns to select the sub-volumes with lesions for the Focus model to segment. Given that the selecting operation is non-differentiable for segmentation training, we propose to employ the segmentation results to reward the Glance model. To optimize the Glance model, we introduce a novel group relative learning paradigm, which employs group relative comparison to prioritize high-advantage predictions and discard low-advantage predictions within sub-volume groups, not only improving efficiency but also reducing false positives. In this way, for the first time, we effectively extend cutting-edge RL techniques to tackle the specific challenges in pan-cancer screening. Extensive experiments on 16 internal and 7 external datasets across 9 lesion types demonstrated the effectiveness of GF-Screen. Notably, GF-Screen leads the public validation leaderboard of MICCAI FLARE25 pan-cancer challenge, surpassing the FLARE24 champion solution by a large margin (+25.6% DSC and +28.2% NSD).

Color fundus photography and Optical Coherence Tomography (OCT) are the two most cost-effective tools for glaucoma screening. Both two modalities of images have prominent biomarkers to indicate glaucoma suspected. Clinically, it is often recommended to take both of the screenings for a more accurate and reliable diagnosis. However, although numerous algorithms are proposed based on fundus images or OCT volumes in computer-aided diagnosis, there are still few methods leveraging both of the modalities for the glaucoma assessment. Inspired by the success of Retinal Fundus Glaucoma Challenge (REFUGE) we held previously, we set up the Glaucoma grAding from Multi-Modality imAges (GAMMA) Challenge to encourage the development of fundus \& OCT-based glaucoma grading. The primary task of the challenge is to grade glaucoma from both the 2D fundus images and 3D OCT scanning volumes. As part of GAMMA, we have publicly released a glaucoma annotated dataset with both 2D fundus color photography and 3D OCT volumes, which is the first multi-modality dataset for glaucoma grading. In addition, an evaluation framework is also established to evaluate the performance of the submitted methods. During the challenge, 1272 results were submitted, and finally, top-10 teams were selected to the final stage. We analysis their results and summarize their methods in the paper. Since all these teams submitted their source code in the challenge, a detailed ablation study is also conducted to verify the effectiveness of the particular modules proposed. We find many of the proposed techniques are practical for the clinical diagnosis of glaucoma. As the first in-depth study of fundus \& OCT multi-modality glaucoma grading, we believe the GAMMA Challenge will be an essential starting point for future research.

DNA-synthesis providers screen incoming orders by searching the requested sequence against curated hazard lists. We show that this baseline collapses to a 100% false-flag rate when the hazardous sequence comes from a taxonomic family absent from the reference set: under Conformal Risk Control's certified miss-rate constraint, a low-discrimination signal forces the threshold below the entire test-benign mass. We compose three signals derived from a synthesis order's public annotation: k-mer Jaccard similarity to known toxins, the trimmed-mean score of a five-LLM judge panel, and cosine similarity to clustered embedding centroids. Fused under a monotone logistic aggregator and calibrated by Conformal Risk Control, the resulting screener certifies E[FNR] le α. Across ten leave-one-taxonomic-family-out folds at α=0.05 on UniProt KW-0800 reviewed toxins, the calibrated screener achieves 0% test miss rate on every fold and 0% test false-flag rate on nine of ten folds. The bound's finite-sample slack 1/(n_{cal}+1) caps the certifiable miss rate at 1.77% on our 200-hazard subsample; reaching procurement-grade α=10^{-3} requires an 18times larger calibration set, which the full reviewed UniProt KW-0800 corpus is large enough to deliver. The binding constraint on certifiable DNA-synthesis screening is calibration data, not algorithms. Code: https://github.com/najmulhasan-code/crc-screen

Lung cancer is the deadliest type of cancer worldwide and late detection is the major factor for the low survival rate of patients. Low dose computed tomography has been suggested as a potential screening tool but manual screening is costly, time-consuming and prone to variability. This has fueled the development of automatic methods for the detection, segmentation and characterisation of pulmonary nodules but its application to clinical routine is challenging. In this study, a new database for the development and testing of pulmonary nodule computer-aided strategies is presented which intends to complement current databases by giving additional focus to radiologist variability and local clinical reality. State-of-the-art nodule detection, segmentation and characterization methods are tested and compared to manual annotations as well as collaborative strategies combining multiple radiologists and radiologists and computer-aided systems. It is shown that state-of-the-art methodologies can determine a patient's follow-up recommendation as accurately as a radiologist, though the nodule detection method used shows decreased performance in this database.

Platform content moderation applies explicit policy rules and context-dependent conditions to decide whether user content is allowed, restricted, or removed. A correct moderation outcome must therefore depend on which rules a case activates, how those rules interact, and whether the available evidence is sufficient. Current multimodal safety benchmarks largely reduce moderation to matching predefined final labels, leaving this underlying rule structure untested. As a result, a high benchmark score reveals little about whether a model applies the policy correctly or arrives at the correct label through superficial cues. To evaluate this rule-governed process, we introduce RuleSafe-VL, a benchmark for rule-conditioned decision reasoning in vision-language content moderation. Derived from publicly available platform moderation policies, RuleSafe-VL formalizes 93 atomic rules and 92 typed rule relations, yielding 2,166 context-sensitive image-text cases across three high-risk policy families. Its four diagnostic tasks decompose moderation into a rule-conditioned decision chain. They identify activated rules, recover rule interactions, judge decision sufficiency, and resolve outcomes once missing context is supplied. Experiments on 10 frontier, open-source, and safety-oriented VLMs reveal rule-relation recovery as the dominant bottleneck, where the best model reaches only 64.8 Macro-F1 and some safety-oriented models fall below 7 Macro-F1. Decision-state prediction also remains unreliable, peaking at 64.5 Macro-F1. RuleSafe-VL shifts moderation evaluation from final-label scoring toward diagnostic assessment of rule-conditioned decision reasoning.

We study reasoning in Rule-Governed Decision Tasks (RGDTs), where models apply external rules to case facts and justify decisions, as required in policy, contract, and compliance settings. Beyond the deductive capability emphasized by standard mathematical and logical reasoning tasks, RGDTs require interpreting rules and their applicability, assessing conditions from evidence, combining judgments under rules and exceptions, and providing checkable justifications. These demands motivate a benchmark assessing both decisions and their stated grounds. We introduce RGDT-Bench, providing 202.1K condition-level supervision slots across four task tracks and eight supported task-probe combinations that vary access to supporting information. Label-blind extraction and deterministic checks produce labels for warrant completeness: source-referenced coverage and consistency of stated decision grounds. The benchmark attributes failures to four process layers: rule use, condition, evidence, and aggregation, and checks the final outcome. Among evaluable correct responses, warrant incompleteness averages 40.2% across six evaluated LLMs and supported task-probe combinations. Such warrant incompleteness poses potential safety risks and remains difficult to detect: the best of seventeen existing evaluators reaches only 57.69% (random: 50%) task-averaged area under the receiver operating characteristic curve (AUROC). To address this difficulty, we train a simple reward model with warrant supervision. It achieves 69.24% task-averaged AUROC among correct answers, exceeding the matched outcome-supervised baseline by 10.37 pp (percentage points) and the best existing evaluator by 11.55 pp. Beyond completeness assessment, the model outperforms both outcome-supervised baselines across nearly all response-selection comparisons, supporting RGDT-Bench's warrant supervision for RGDT reasoning.

LLM rerankers add of the order of \$0.2-0.3 per 1,000 queries and about a second of tail latency on top of a graph-augmented dense pipeline such as HippoRAG2, and on three multi-hop benchmarks they improve final-hop top-K coverage on seven of nine (dataset, K) cells, by up to +34.8 pp. We ask whether a learned per-query gate can skip the reranker where it will not help, using only features available before the LLM call (27 score and lexical statistics of the two retrieval lists plus a PCA of a small query embedding) with an executable fallback. Every choice, including the fallback and the threshold, is made inside the training fold and applied once to held-out queries, and harmful skips (the rerank would have found the target, the fallback did not) are reported next to the aggregate coverage. Across nine cells on 2WikiMultiHopQA, MuSiQue and HotpotQA the gate skips 51% of calls at an average held-out LastHop@K cost of 1.2 pp; four cells meet a pre-registered 1 pp rule, harmful skips occur in eight (190 harmful against 136 beneficial), and a random gate at the same skip rate loses 2 to 11 pp on the high-lift cells. A second rule sets each cell's threshold from a pre-specified budget on the expected harmful-skip rate over Platt-calibrated harm probabilities (ECE 0.025 after calibration, 0.094 before): at a 1 pp budget the gate skips 42% at -0.8 pp with 66 harmful skips and six cells within 1 pp, but realised harm exceeds the promise in six cells (mean 1.45 vs 0.83 pp), a selection optimism we quantify; a 0.5 pp budget realises about 1 pp. The harm probabilities are calibrated but barely discriminative (AUC 0.16 to 0.70). An earlier version reported 73% "lossless" savings; that figure rested on an oracle fallback and a wrong MuSiQue target, and we document both.

Medical artificial intelligence (AI) models are often shared without their training data, assuming this protects the patients who contributed them. However, a model can reveal whether a patient's records were used in training, a privacy breach known as a membership inference attack. This risk is usually reported as a cohort average, which can appear negligible while individual patients are almost certainly exposed. Identifying potentially vulnerable records before developing a production model could make privacy assessment more practical. We measured each patient's vulnerability to membership inference attack, across 7,789 models trained on six clinical datasets in four modalities, including two adapted pretrained medical models. Training choices changed how many patients had high attack scores, but the patients who ranked highest by risk largely stayed the same across the configurations we tested. Stronger weight decay reduced the exposed cohort up to threefold, yet largely the same patients remained most at risk across training recipes, architectures and initializations, including foundation models. Therefore, we developed a lightweight screening tool that uses four small models to identify patients with high risk of exposure before production-model training. We also assessed if flagged patients could be protected without removing their data. Privacy screening should become incorporated into data preparation for clinical AI.

"IMDb" as a user-regulating and one the most-visited portal has provided an opportunity to create an enormous database. Analysis of the information on Internet Movie Database - IMDb, either those related to the movie or provided by users would help to reveal the determinative factors in the route of success for each movie. As the lack of a comprehensive dataset was felt, we determined to do create a compendious dataset for the later analysis using the statistical methods and machine learning models; It comprises of various information provided on IMDb such as rating data, genre, cast and crew, MPAA rating certificate, parental guide details, related movie information, posters, etc, for over 79k titles which is the largest dataset by this date. The present paper is the first paper in a series of papers aiming at the mentioned goals, by a description of the created dataset and a preliminary analysis including some trend in data, demographic analysis of IMDb scores and their relation of genre MPAA rating certificate has been investigated.

Breast cancer screening plays a pivotal role in early detection and subsequent effective management of the disease, impacting patient outcomes and survival rates. This study aims to assess breast cancer screening rates nationwide in the United States and investigate the impact of social determinants of health on these screening rates. Data on mammography screening at the census tract level for 2018 and 2020 were collected from the Behavioral Risk Factor Surveillance System. We developed a large dataset of social determinants of health, comprising 13 variables for 72337 census tracts. Spatial analysis employing Getis-Ord Gi statistics was used to identify clusters of high and low breast cancer screening rates. To evaluate the influence of these social determinants, we implemented a random forest model, with the aim of comparing its performance to linear regression and support vector machine models. The models were evaluated using R2 and root mean squared error metrics. Shapley Additive Explanations values were subsequently used to assess the significance of variables and direction of their influence. Geospatial analysis revealed elevated screening rates in the eastern and northern United States, while central and midwestern regions exhibited lower rates. The random forest model demonstrated superior performance, with an R2=64.53 and root mean squared error of 2.06 compared to linear regression and support vector machine models. Shapley Additive Explanations values indicated that the percentage of the Black population, the number of mammography facilities within a 10-mile radius, and the percentage of the population with at least a bachelor's degree were the most influential variables, all positively associated with mammography screening rates.

We consider a binary classification problem under group fairness constraints, which can be one of Demographic Parity (DP), Equalized Opportunity (EOp), or Equalized Odds (EO). We propose an explicit characterization of Bayes optimal classifier under the fairness constraints, which turns out to be a simple modification rule of the unconstrained classifier. Namely, we introduce a novel instance-level measure of bias, which we call bias score, and the modification rule is a simple linear rule on top of the finite amount of bias scores.Based on this characterization, we develop a post-hoc approach that allows us to adapt to fairness constraints while maintaining high accuracy. In the case of DP and EOp constraints, the modification rule is thresholding a single bias score, while in the case of EO constraints we are required to fit a linear modification rule with 2 parameters. The method can also be applied for composite group-fairness criteria, such as ones involving several sensitive attributes.

We consider the classic supervised learning problem, where a continuous non-negative random label Y (i.e. a random duration) is to be predicted based upon observing a random vector X valued in R^d with dgeq 1 by means of a regression rule with minimum least square error. In various applications, ranging from industrial quality control to public health through credit risk analysis for instance, training observations can be right censored, meaning that, rather than on independent copies of (X,Y), statistical learning relies on a collection of ngeq 1 independent realizations of the triplet (X, ; min{Y,; C},; δ), where C is a nonnegative r.v. with unknown distribution, modeling censorship and δ=I{Yleq C} indicates whether the duration is right censored or not. As ignoring censorship in the risk computation may clearly lead to a severe underestimation of the target duration and jeopardize prediction, we propose to consider a plug-in estimate of the true risk based on a Kaplan-Meier estimator of the conditional survival function of the censorship C given X, referred to as Kaplan-Meier risk, in order to perform empirical risk minimization. It is established, under mild conditions, that the learning rate of minimizers of this biased/weighted empirical risk functional is of order O_{P}(log(n)/n) when ignoring model bias issues inherent to plug-in estimation, as can be attained in absence of censorship. Beyond theoretical results, numerical experiments are presented in order to illustrate the relevance of the approach developed.

We present the design and implementation of a custom discrete optimization technique for building rule lists over a categorical feature space. Our algorithm produces rule lists with optimal training performance, according to the regularized empirical risk, with a certificate of optimality. By leveraging algorithmic bounds, efficient data structures, and computational reuse, we achieve several orders of magnitude speedup in time and a massive reduction of memory consumption. We demonstrate that our approach produces optimal rule lists on practical problems in seconds. Our results indicate that it is possible to construct optimal sparse rule lists that are approximately as accurate as the COMPAS proprietary risk prediction tool on data from Broward County, Florida, but that are completely interpretable. This framework is a novel alternative to CART and other decision tree methods for interpretable modeling.

We propose a criterion for discrimination against a specified sensitive attribute in supervised learning, where the goal is to predict some target based on available features. Assuming data about the predictor, target, and membership in the protected group are available, we show how to optimally adjust any learned predictor so as to remove discrimination according to our definition. Our framework also improves incentives by shifting the cost of poor classification from disadvantaged groups to the decision maker, who can respond by improving the classification accuracy. In line with other studies, our notion is oblivious: it depends only on the joint statistics of the predictor, the target and the protected attribute, but not on interpretation of individualfeatures. We study the inherent limits of defining and identifying biases based on such oblivious measures, outlining what can and cannot be inferred from different oblivious tests. We illustrate our notion using a case study of FICO credit scores.

Bank credit risk is a significant challenge in modern financial transactions, and the ability to identify qualified credit card holders among a large number of applicants is crucial for the profitability of a bank'sbank's credit card business. In the past, screening applicants'applicants' conditions often required a significant amount of manual labor, which was time-consuming and labor-intensive. Although the accuracy and reliability of previously used ML models have been continuously improving, the pursuit of more reliable and powerful AI intelligent models is undoubtedly the unremitting pursuit by major banks in the financial industry. In this study, we used a dataset of over 40,000 records provided by a commercial bank as the research object. We compared various dimensionality reduction techniques such as PCA and T-SNE for preprocessing high-dimensional datasets and performed in-depth adaptation and tuning of distributed models such as LightGBM and XGBoost, as well as deep models like Tabnet. After a series of research and processing, we obtained excellent research results by combining SMOTEENN with these techniques. The experiments demonstrated that LightGBM combined with PCA and SMOTEENN techniques can assist banks in accurately predicting potential high-quality customers, showing relatively outstanding performance compared to other models.

Checklists are simple decision aids that are often used to promote safety and reliability in clinical applications. In this paper, we present a method to learn checklists for clinical decision support. We represent predictive checklists as discrete linear classifiers with binary features and unit weights. We then learn globally optimal predictive checklists from data by solving an integer programming problem. Our method allows users to customize checklists to obey complex constraints, including constraints to enforce group fairness and to binarize real-valued features at training time. In addition, it pairs models with an optimality gap that can inform model development and determine the feasibility of learning sufficiently accurate checklists on a given dataset. We pair our method with specialized techniques that speed up its ability to train a predictive checklist that performs well and has a small optimality gap. We benchmark the performance of our method on seven clinical classification problems, and demonstrate its practical benefits by training a short-form checklist for PTSD screening. Our results show that our method can fit simple predictive checklists that perform well and that can easily be customized to obey a rich class of custom constraints.

The objective is the design of a Cellular Automata rule that can form patterns with 'touching' loops. A loop is defined as a closed path of 1-cells in a 2D grid on a zero background and with a zero border. A path cell is connected with two of its adjacent neighbors. In touching loops a path cell is also allowed to touch another on a diagonal. A CA rule was designed that can evolve stable touching loop patterns. The rule tries to cover the 2D space by overlapping tiles. The rule uses so-called templates, 5 x 5 matching patterns which are systematically derived from the given set of 3 x 3 tiles. The rule checks the pattern being evolved against a list of templates. If the outer neighbors of a template match, then the cell's state is set to the template's center value. Noise is injected if there is no matching template, or the tiles are not properly assembled. Thereby the evolution is driven to the desired loop patterns.

Safeguards in deployed LLM services are evaluated by refusal, attack success, and policy violation rates. Those rates characterize how a control performed on the requests it was tested on. A deployment has to answer a different question: how much help with harmful tasks the service still gives an attacker who keeps adapting or finds another way in. We determine what each reported result implies for that question, allowing results from different safeguard families to be compared under one deployment criterion. The evidence requirements are strongly asymmetric. One attack that obtains harmful help from the deployed service suffices to establish that such help remains, and such attacks appear repeatedly in the coded record. Establishing that little remains cannot follow from the safeguard's own numbers alone; it also requires evidence about what the surrounding system still allows after the safeguard performs its local function. Such evidence is supported or derived in only a small minority of the depth-coded claims, and one such claim bounds its scoped residual. A better local score is therefore not, by itself, a stronger claim about the deployment. Safeguard research cannot stop at raising local scores; a gain has to be judged by whether it makes a deployed system any safer.

A movie that is thoroughly enjoyed and recommended by an individual might be hated by another. One characteristic of humans is the ability to have feelings which could be positive or negative. To automatically classify and study human feelings, an aspect of natural language processing, sentiment analysis and opinion mining were designed to understand human feelings regarding several issues which could affect a product, a social media platforms, government, or societal discussions or even movies. Several works on sentiment analysis have been done on high resource languages while low resources languages like Yoruba have been sidelined. Due to the scarcity of datasets and linguistic architectures that will suit low resource languages, African languages "low resource languages" have been ignored and not fully explored. For this reason, our attention is placed on Yoruba to explore sentiment analysis on reviews of Nigerian movies. The data comprised 1500 movie reviews that were sourced from IMDB, Rotten Tomatoes, Letterboxd, Cinemapointer and Nollyrated. We develop sentiment classification models using the state-of-the-art pre-trained language models like mBERT and AfriBERTa to classify the movie reviews.

Systematic reviews require sustained human judgment across thousands of records, yet existing evaluations of large language models (LLMs) typically examine review stages in isolation. We introduce SciLitBench, a multi-stage benchmark spanning title and abstract screening, full-text screening, and schema-guided data extraction, with 42,981 retrieved records, 1,012 full texts, and annotations for 888 included papers. Across 22 open-weight LLMs from six model families, explicit inclusion and exclusion criteria improve title and abstract screening F_2 by 28.8\%, while researcher-authored rationales improve full-text screening by 15\%. Data extraction reveals a different reliability regime: performance declines from 0.97 accuracy for publication year to 0.37 Jaccard overlap for computational approach, while the strongest models recover only 30\% of annotated evaluation evidence and 25\% of limitations. SciLitBench identifies a practical boundary between high-recall screening and evidence-complete extraction and provides a reproducible resource for evaluating LLM-assisted evidence synthesis.

An agent that inherits six one-line memories may pull at most one archived source record before acting; a directive written into the store can steer that choice: a pointer to the record, a criterion that identifies it, or both. Across twelve registered studies on one instrument lineage (14,760 attempts) we measured where the request goes under each form. On six direct-provider models a length-matched criterion exceeded a bare id by +35.0 points [+31.2, +38.8] (Study D); the contrast failed its registered superiority rule on a nine-model OpenRouter-served panel (Study E). Appending the id cancelled the criterion on three Claude models (Opus 5: 40/40 to 0/40; Study F-x); six byte-matched edits gave each exact string its own effect (Study G), and a re-run at eighty runs per cell left fifteen of thirty replication contrasts within the margin, fifteen unresolved and none beyond (Study G'). A ratification line (+96.0 points on Opus 5) and a budget of two credits restored the target on all three (Study J); across five criterion strings the suffix's cancellation held for four of the five wordings on Opus 5 and all five wordings on Fable 5.1 (Study H2); in a second store every model followed the criterion (Study H1). Continued into a decision, the criterion moved the choice toward the current record (+100.0 points, Opus 5) and away from it on Fable 5.1 (Study I). A one-character plan pointer's effect (+78.0 points; Study B, after a correction of its first repository report) returned the same verdict under a prospectively registered re-run (+81.7 points; Study B'). All results are descriptive effects of exact edits on fixed panels with registered intervals and no mechanism claim.

Frontier language models excel at complex tasks yet may prioritize protection over larger physical consequences in simple, urgent decisions. GPT-5.6 Sol, for example, moves a girl playing in shallow water before retrieving a submerged camera. We call this Protection Mode and study it with ProtectionBench: 285 prompts, 34 physical families, and nine models. At lowest effort, at least one of four responses prioritizes the subject on 34.74% of Sol prompts and over 83% of MiniMax M3 and Qwen3.5-27B prompts; none of four independent human raters does so. Controls show that choices usually track physical risk. We elicit both risks before requesting an action. Some models assess risk incorrectly; others state the correct ordering but still choose the subject. Qwen3.5-27B with thinking shows 100% correct risk ordering but 57.81% subject choice among eligible conversations on eight selected scenes. Attention audits find no stable reduction in attention to relevant facts; removing the stated risk direction reduces object-first choice in dots3-note-prev but not detectably in Qwen3.5-27B. Adding a general "people or animals before property" rule increases subject choice by 19-38 percentage points, whereas factual reminders favor the object by 0.7-5.2 points. Removing naturally generated versions of that rule lowers subject choice by 10-15 points. We also examine whether post-training introduces this pattern. Base models already show Protection Mode; post-training changes justifications more than choices.

The growth rate of Av(1324) is the last unknown Stanley-Wilf limit of a length-four pattern. Since 2020 the best rigorous lower bound has been the 10.271012 of Bevan, Brignall, Elvey Price and Pantone; we raise it to 10.412263. Their construction lays 1324-avoiders along an infinite staircase of two-cell blocks alternating with single connecting cells, and forbids a 1324 by a local condition on how the points of a block interleave with the components of the cell beside it. Certain points of a block, its leaves, may be exempted from that condition. They exempt them on one axis only, and report that they could not count the possibilities when both are exempted. This paper exempts them on both axes and counts the result. The second relaxation is their own argument read in the other axis, and the Harris correlation inequality bounds the joint count below by the product of the two counts taken separately, at the cost of one factor of the component generating function.

Serving an answer from a large language model requires deciding when to abstain, yet a verifier's ranking accuracy alone does not determine the error rate among served answers. We introduce PriceCheck, which builds a compact family of decision rules from label-free checks such as re-solving a problem. Each check has a price: its agreement rates on correct and incorrect answers and its cost per run. Prices fitted on a small, class-enriched labelled set compose into predictions of a schedule's coverage and cost, guiding which checks to run and when to stop. A calibration test then selects a schedule at a stated selective-risk target. In mathematics, the selected schedules serve 76.1% of answers on average and keep held-out selective risk below 1.5% on all 15 splits. Under the shared testing protocol, PriceCheck serves more answers at that target than reward models, a prompted judge, the generator's confidence and a trained correctness classifier. At matched coverage, it keeps the fewest wrong answers among these scorers. Across 118 diagnostic schedules, price-based coverage predictions have a rank correlation of 0.97 with observed coverage. These results show that choosing how checks are combined and stopped matters alongside how well a verifier ranks answers. Code is available at https://github.com/js-lee-AI/PriceCheck.

A voice agent can handle almost every call on the words alone and still fail the few its sector's rules were written for. Emergency-call standards, fraud guidance, radio phraseology and vulnerability rules recognise that how a caller sounds, or what else is audible, can change the right action. VoxParity tests whether agents act on it. In 183 scenarios from 14 sectors, one transcript stays fixed while the audio changes (a coaching voice, a medical monitor beeping, a mayday under a radio check, noise over a drug name, a child's voice placing a bet, a frightened whisper), and with it the correct typed tool call. A words-only null test credits a system only if hearing the call moves its actions more than it moves a pipeline that only reads the words. Only 11 of the 23 systems that can also be run on the transcript pass. Descriptively, errors run toward the words: when the audio calls for protection, all 28 systems carry out the routine request more often than they over-react on clean calls (41% against 12% pooled; the words-only pipeline, 58% against 15%). Exploratory analyses place most of the leading systems' misses on cues they heard; systems beat the null almost entirely on items that state the rule; the leading systems overrule heard resignation or confusion far more often than acute alarm; and, in the models tested, describing the voice and stating the rule each recover part of the shortfall, leaving a gap on emotion.